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ADVERSE EFFECTS OF ADJUVANTS IN VACCINES by Viera Scheibner (Part 1 & 2)
Aluminum in Vaccines Produce Nodules Cutaneous Pseudolymphoma Tied to Vaccinations Containing Aluminum Hydroxide
Research carried out by Christine, posting on Babycenter
Aluminium and injection site reactions
Variation of abscess formation in cattle after
vaccination with a modified-live Pasteurella
haemolytica vaccine.
Variation of abscess formation in cattle after
vaccination with a modified-live Pasteurella
haemolytica vaccine
“Compared with calves given MLV that did not develop
observable abscesses, calves developing abscesses after
the second injection of MLV weighed 11.0 and 14.2 kg
less, respectively, at 56 days and 112 days after
injection, and they had 11.0 kg less gain at 56 days
after injection. Abscess prevalence tended to be
highest on certain days or at certain locations used
for cattle processing, and the prevalence of abscesses
increased in cattle processed later on a given day.”
And ya gotta love this one, save the fish, sacrifice the children...
Vaccinated fish welfare: protection versus side-effects.
Vaccinated fish welfare: protection versus side-effects
“Intraperitoneal administration of oil-adjuvanted
vaccines to Atlantic salmon pre-smolts has occasionally
resulted in impaired growth and reduced carcass
quality. The consequences of such vaccination for fish
welfare may therefore be questioned.”
and “In intensive salmon aquaculture systems, reduced
disease risks are thought to justify the observed level
of side-effects following current vaccination
practices. For future fish vaccines, reduction of side-
effects without compromising long-term protective
immunity constitutes a challenging goal.”
Pathological studies on local tissue reactions in
guinea pigs and rats caused by four different adjuvants.
Pathological studies on local tissue reactions in
guinea pigs and rats caused by four different adjuvants.
“In the animals injected with ISA-70 emulsion prepared
by manual shaking, grossly, there was partial
thickening of subcutaneous tissue, discoloration of
inter-muscular connective tissue, and swelling of the
inguinal lymph nodes at 2 and 4 weeks post injection
(PI). Histopathologically, ISA-70 injected sites
revealed acute inflammatory changes at 72 hrs PI, and
peak reactions consisting of macrophage accumulation
around oil cysts and fibrosis were observed at 4 weeks
PI. These changes were less severe and of shorter
duration than those in the other three adjuvants.”
[Specifically, Freund's incomplete adjuvant, Freund's
complete adjuvant, and aluminium phosphate gel.]
Comparison of tissue reactions produced by Haemophilus
pleuropneumoniae vaccines made with six different
adjuvants in swine.
Comparison of tissue reactions produced by Haemophilus
pleuropneumoniae vaccines made with six different
adjuvants in swine.
Adjuvants--a balance between toxicity and adjuvanticity.
Adjuvants--a balance between toxicity and adjuvanticity
Aluminium-adjuvanted vaccines transiently increase
aluminium levels in murine brain tissue.
Aluminum allergy caused by DTP vaccine
Adjuvants for human vaccines--current status, problems
and future prospects
“Biodegradable polymer microspheres are being evaluated
for targeting antigens on mucosal surfaces and for
controlled release of vaccines with an aim to reduce
the number of doses required for primary immunization.
Reciprocal enhanced immunogenicity of protein-
polysaccharide conjugates will be useful for the
development of combination vaccines.”
[Progress is great, but in the meantime, how many more
children will fall victims to a well intended program
gone bad?]
Aluminum as an adjuvant in vaccines and post-vaccine
reactions].
Aluminum as an adjuvant in vaccines and post-vaccine
reactions
“Tissue damage caused by six different adjuvants
incorporated in a Haemophilus pleuropneumoniae vaccine
was compared in swine.” .... “The aluminum hydroxide
produced smaller lesions that also persisted for eight
weeks”.
“The chemical nature of adjuvants, their mode of action
and the profile of their side effects are highly
variable. Some of the side effects can be ascribed to
an unintentional stimulation of different mechanisms of
the immune system whereas others may reflect general
adverse pharmacological reactions” ... “. At present
the choice of adjuvants for human vaccination reflects
a compromise between a requirement for adjuvanticity
and an acceptable low level of side effects.”
“It is likely that aluminium is transported to the
brain by the iron-binding protein transferrin and
enters the brain via specific transferrin receptors.”
“immunization of children who have been shown to be
allergic to aluminium should be carried out with
vaccines which do not contain aluminium.” [And how
do we know that our child is allergic to aluminum (or
to any other components of the vaccine) until they are
given the injection? Who knows if their newborn or 2
month old is allergic to anything at that young of age?]
“The biggest issue with the use of adjuvants for human
vaccines, particularly routine childhood vaccines, is
the toxicity and adverse side-effects of most of the
adjuvant formulations. At present the choice of
adjuvants for human vaccination reflects a compromise
between a requirement for adjuvanticity and an
acceptable low level of side-effects.” [I don’t know
about you, but “tolerable” and “good enough” as
synonyms for acceptable just don’t get it when it comes
to my children. Who do I let decide what
is “tolerable” for my child?
[another scary admission]
“The mechanism of action of the aluminium adjuvants is
not completely understood and is very complex.”
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